Antidepressant Unwanted Effects Including Weight, BP Variations Vary Depending on Medication

• A comprehensive new research determined that the adverse reactions of antidepressant medications differ substantially by drug.
• Some medications resulted in decreased mass, while different drugs resulted in weight gain.
• Pulse rate and arterial pressure furthermore diverged markedly across drugs.
• Individuals suffering from persistent, intense, or worrisome side effects ought to consult a healthcare professional.

New studies has found that depression drug unwanted effects may be more varied than earlier believed.

The large-scale investigation, issued on the 21st of October, analyzed the impact of antidepressant drugs on more than 58,000 participants within the beginning eight weeks of commencing treatment.

The researchers studied 151 research projects of 30 medications commonly used to treat clinical depression. While not all individuals experiences side effects, several of the most prevalent recorded in the investigation were variations in weight, arterial pressure, and metabolic indicators.

Researchers observed striking variations between antidepressant drugs. For instance, an two-month course of agomelatine was associated with an mean weight loss of around 2.4 kg (approximately 5.3 pounds), whereas maprotiline users increased close to 2 kg in the equivalent duration.

Furthermore, notable variations in heart function: one antidepressant often would slow cardiac rhythm, in contrast nortriptyline raised it, creating a difference of about 21 heartbeats per minute among the two medications. BP varied also, with an 11 millimeters of mercury variation seen between nortriptyline and doxepin.

Healthcare experts observed that the investigation's findings are not considered novel or surprising to mental health professionals.

"Clinicians have long recognized that various antidepressants vary in their impacts on weight, BP, and additional metabolic parameters," a specialist stated.

"Nevertheless, what is remarkable about this research is the thorough, relative assessment of these differences throughout a wide array of physical indicators utilizing findings from in excess of 58,000 individuals," this specialist noted.

The investigation delivers strong proof of the degree of side effects, certain of which are more frequent than other effects. Frequent antidepressant side effects may encompass:

• stomach problems (sickness, diarrhea, blockage)
• sexual dysfunction (decreased libido, orgasmic dysfunction)
• mass variations (gain or reduction, depending on the agent)
• sleep problems (inability to sleep or sedation)
• oral dehydration, moisture, headache

Meanwhile, less frequent but medically important unwanted effects may comprise:

• increases in blood pressure or cardiac rhythm (notably with SNRIs and certain tricyclics)
• reduced blood sodium (notably in senior patients, with SSRIs and SNRIs)
• increased liver enzymes
• QTc prolongation (risk of arrhythmia, especially with one medication and some tricyclic antidepressants)
• emotional blunting or apathy

"An important point to note here is that there are multiple varying types of depression drugs, which result in the different adverse medication reactions," a different professional commented.

"Furthermore, antidepressant medications can affect each person variably, and unwanted reactions can range based on the particular drug, amount, and individual considerations like metabolic rate or co-occurring conditions."

Although some side effects, including changes in rest, hunger, or stamina, are quite common and often enhance as time passes, others may be less frequent or more persistent.

Depression drug unwanted effects may differ in seriousness, which could warrant a adjustment in your drug.

"An modification in antidepressant medication may be appropriate if the patient experiences continuing or unbearable unwanted effects that don't get better with passing days or supportive care," a expert said.

"Moreover, if there is an development of new health problems that may be worsened by the existing medication, such as hypertension, abnormal heart rhythm, or significant mass addition."

You may additionally contemplate consulting with your physician concerning any lack of meaningful progress in depression-related or anxiety symptoms following an appropriate trial period. The sufficient evaluation duration is usually 4–8 weeks duration at a therapeutic dosage.

Individual choice is furthermore important. Certain individuals may prefer to avoid specific side effects, such as intimacy issues or {weight gain|increased body weight|mass addition